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Neuroanatomy studies revealed that hippocampus volume appeared to be reduced in the brains of depression patients ( 2.5 Miscellaneous theories Scientists proposed several other conjectures of depression including inflammation theory, gut microbiota theory, glial pathology theory, epigenetic theory, infection theory, and dys-stress theory ( 2.6 Current antidepressants and limitations FDA-approved antidepressant drugs for adults are divided into seven categories: selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), tricyclic and tetracyclic antidepressants (TCAs and TeCAs), atypical antidepressants, monoamine oxidase inhibitors (MAOIs), N-methyl D-aspartate (NMDA) antagonist, neuroactive steroid, gamma-aminobutyric acid (GABA)-A receptor positive modulator ( Most of synthetic antidepressant drugs are known to frequently cause severe side effects and exhibit symptoms including dizziness, nausea, weight change, sexual dysfunction, and apathy (Table 1
