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There is a need for large, well designed studies that link metabolites, co-factors and genes of the -glutamyl cycle and trans-sulphuration pathway with objective behavioural outcomes to be conducted in children with autism spectrum disorders

A 2025 pilot study published in PubMed confirmed short-term tolerance in 2 participants at 20mg intravenously, though the sample size remains too limited for definitive safety conclusions

As a secondary goal, we explored the functional effects of NPW (indexed by relative cerebral blood flow, rCBF) on the pituitary (related to stress and HPA stimulation) [15, 19] and habenula (implicated in NAL aversion) [20]

35 mg (0.090.15 mL)