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Because Tirzepatide slows gastric emptying, some patients experience nausea, discomfort, or digestive issues especially during dose escalation

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While not directly sleep-related, systemic inflammation is a well-established disruptor of sleep quality Autoimmune myocarditis (FASEB J, 2017) -- attenuation of disease via Treg generation, further establishing anti-inflammatory potential Structure-activity studies (Nature Communications, 2021) -- investigation of analogs with improved selectivity, suggesting potential future clinical development No human studies have been conducted for cortistatin in any indication, including sleep