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These studies have found a significant reduction in white matter volume and alterations in the integrity of myelin that suggest deterioration during aging (Pakkenberg and Gundersen, 1997

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In mice, the ototoxicity could be mitigated or reversed with NAC.[ref] Gastric bleeding: Similar to NSAIDs, acetaminophen can also increase the risk of gastrointestinal bleeding or ulcers

Furthermore, recent studies have indicated that p53 may regulate the abnormal differentiation of osteoclasts through the p53/forkhead box protein O3 (FOXO3) signaling pathway, thereby modulating ferroptosis in chondrocytes (Zhao et al., 2025)