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We highlight the clinical implications of disturbances in physiological brainheart communication for various clinical conditions, including Takotsubo syndrome resulting from emotional stress or from brain disorders, cardiac complications after stroke (so-called strokeheart syndrome), and cognitive dysfunction in patients with cardiac diseases such as heart failure and atrial fibrillation

A number of researchers have reported that the activation of the SphK1/S1P signaling pathway marks the occurrence of autoimmune diseases, and the up-regulation of SphK1 is related to the pathogenesis of multiple sclerosis (Luo et al., 2017)

Drug Discovery 7 (10), 854868

Track response with oxidative stress and redox labs (e.g., MDA/TBARS, GSH:GSSG ratio, hs-CRP) and adjust dose if skin irritation or detox symptoms occur