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In some cases, this can persist for weeks and further reduce appetite or nutrient absorption during a critical healing phase These factors are important because inflammation that is happening in the gut can reach the brain and potentially worsen post-concussion symptoms like brain fog, mood swings, or fatigue

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Future studies should emphasize comprehensive mechanistic validationsuch as gene-level modulationalongside in vivo efficacy testing and translational assessments, including pharmacokinetic profiling and toxicological evaluation

Mechanisms of intermittent hypoxia-mediated macrophage activation - potential therapeutic targets for obstructive sleep apnoea