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The C-terminal domain contributes, together with the N-terminal domain, to shaping the co-substrate binding site, which is termed H-site, from the hydrophobic nature of co-substrates

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However, in IH LATE , where IH is experienced after the first critical period and during the final stages of neurogenesis, the neuronal proportions generated by HIF1a +/- and wildtype NSCs were similar to one another (Supplemental Figure S3C)