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We defined two sets of genes, those either largely devoid of promoter bound NRF2 (Group I, green) or genes with high promoter bound NRF2 (Group II, purple) (Fig

Consult your doctor if any of these side effects worsens

They discovered that the binding of a peptide mimicking the MDM4 C-terminus tail to MDM2 impairs MDM2-mediated ubiquitination of p53 and promotes p53-dependent transcription and oncosuppressive activities [57]