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Interestingly, microbial metabolism also has a strong impact on cytokine production, which is mainly mediated by the tryptophan metabolite tryptophol that has strong inhibitory effects on the TNF- response [121]

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112 in their studies on inhibitors of apoptosis in a trial to protect the ovary after DOX therapy concluded that DOX diminished primordial follicular reserve through the induction of apoptosis of GCs and oocyte which is parallel to the findings of the present histological sections of rat ovaries immunohistochemical stained with antiP53 and anticaspase-3 bodies

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